Given the ubiquitous but varying degrees of olfactory dysfunction among various neurodegenerative disorders, the key question is whether damage to a common primordial neuropathological substrate is the basis for the perceptual differences in olfaction or whether disease-specific or other entities, such as respiratory infections or pollution, are responsible. Considering the early preclinical onset of smell deficits in many neurodegenerative diseases, the answer to this question might provide crucial insight into the cause of disease pathology at its earliest stages of development.
Usually, people >65 of age have some form of olfactory dysfunction, ranging from mild loss (mild hyposmia) to total loss (anosmia) which substantially affects the well-being and quality of life that further increases the risk from fire, environmental toxins, leaking natural gas, and spoiled food. Factors…
