A recent a population-based cohort study of women on long-term Bisphosphonates (BP) therapy that evaluated the rate of hip fracture following a drug holiday reported that those women stopping BP treatment for more than 2 years were 40% more likely to develop hip fractures. The study was presented at the American College Of Rheumatology. Study design Inclusion criteria: The study included all the women who initiated a BP and were at least 80% adherent to their BP treatment for ≥3 years were identified, and data were collected from them. Exclusion criteria: The patients who were on other bone therapies such as on denosumab, estrogen, teriparatide, calcitonin was excluded from the study.
The crude rates of hip fracture for continuing BP therapy were calculated. Among those women who discontinued BP therapy, length of drug holiday extending up to 3 years was calculated. A Cox proportional…
