A large study published by The BMJ of over 3 million pregnancies has found no link between metformin use by fathers with type 2 diabetes and birth defects in their offspring. The research, which analyzed data from Norway and Taiwan, concluded that metformin remains a suitable treatment for managing blood sugar levels in men planning to have children. The study involved over 600,000 pregnancies in Norway and 2.5 million in Taiwan and found no significant increase in congenital malformations among offspring of fathers who used metformin during the sperm development period, once adjusted for other factors like the father's age and health conditions.
Although earlier research in Denmark suggested a potential connection between metformin use and genital malformations in male infants, this new study did not find evidence to support such a risk. After accounting for genetic and family factors,…
