A complex pediatric liver cancer that once offered no realistic surgical options was recently managed successfully at a hospital in Mumbai using an advanced ex situ liver resection and autotransplantation technique. This marks the first reported use of this approach in India for a child with advanced hepatoblastoma. The patient, just over three years old at the time of surgery, had been diagnosed months earlier with hepatoblastoma involving approximately 70 to 80% of the liver. Detailed evaluation by the head of pediatric surgery and solid organ transplantation revealed a centrally located tumor encasing major hepatic vessels.

The extent and location of vascular involvement made conventional liver resection unsafe. Initial chemotherapy achieved partial tumor shrinkage and allowed limited regeneration of healthy liver tissue. Despite this response, venous outflow obstruction persisted,…