Type 2 diabetes mellitus in older adults is associated with a substantially increased risk of cardiovascular disease, underscoring the need for effective adjunctive therapeutic strategies. Synbiotic supplementation has shown potential in improving gut microbiota, metabolic control, and cardiovascular risk factors, but its efficacy in elderly patients with T2DM remains unclear. To address this gap, a study has evaluated the effects of multi-species synbiotic supplementation in 85 elderly individuals with T2DM and high cardiovascular risk.
The study found that synbiotic supplementation significantly improved anthropometric, metabolic, and cardiovascular risk markers compared with placebo, reducing body weight by 1.16 kg, BMI by 0.44 kg/m², and body fat mass by 0.99 kg. Significant improvements were also observed in Low-density-Lipoprotein (LDL-C) (−10.83 mg/dL), total cholesterol (−11.78…
