Several small cohort studies have reported a link between maternal sexually transmitted infections (STIs) and adverse pregnancy outcomes, though most have focused on a single pathogen. To investigate this further, a population-based retrospective study in Australia examined the effects of chlamydia, gonorrhea, trichomoniasis, and syphilis infections during pregnancy on perinatal outcomes in 59,465 singleton births. The study revealed that congenital syphilis was significantly associated with preterm birth (relative risk [RR]: 3.34) and small-for-gestational-age (RR: 2.22).
Maternal infections with chlamydia (RR: 1.86), gonorrhea (RR: 1.76), and trichomoniasis (RR: 1.10) were also linked to an increased risk of small-for-gestational-age births. Additionally, gonorrhea was associated with a higher risk of stillbirth (RR: 1.97), while trichomoniasis was linked to preterm birth (RR: 1.23).…
