Thrombotic thrombocytopenic purpura (TTP) is a life- threatening clinicopathological blood disorder characterized by clotting in small blood vessels of the body, resulting in a low platelet count. If not treated promptly it leads to further deterioration causing irreversible renal failure, progressive neurologic deterioration, cardiac ischemia, and death. The current article describes a case study of a 24-year-old female with TTP, unresponsive to plasmapheresis and was treated successfully with vincristine. TTP is a rare blood disorder which remains a management challenge to the physicians.
Patients with TTP generally presents with an acute or subacute onset of symptoms related to neurologic dysfunction, anemia, or thrombocytopenia. TTP has a specific pathogenetic defect characterized by a deficiency in metalloprotease ADAMTS13. In its full-blown form, the disease consists of the…
