Drug Molecule Information Estradiol is the primary female sex hormone used in postmenopausal women for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. The drug is used as a topical cream. This article will provide a short summary of topical estradiol. Estradiol or 17-β-estradiol is the primary sex hormone. It is the key regulator of estorus and menstrual cycle in women and is also important in the development and maintenance of female reproductive organs.

Though estrogen is synthesized in both men and women, its levels are very lower in males. In females, ovaries predominantly synthesize estradiols in follicles. Thus, as the women reach menopause, the synthesis of estradiol is also reduced. Due to these hormonal changes, women may suffer from various conditions including hot flashes, vulvar and vaginal atrophy. To gain the control of these…