According to a study publihed in BMJ, Trimethoprim is linked with an increased risk of acute kidney injury (AKI) and hyperkalemia when compared with other antibiotics used to treat UTIs. The study was aimed to determine if trimethoprim use in UTI is associated with a greater risk of AKI, hyperkalemia, or sudden death in the general population. The odds of AKI in the 14 days following antibiotic initiation were higher following trimethoprim (adjusted odds ratio 1.72, 95% confidence interval 1.31 to 2.24) and ciprofloxacin (1.48, 1.03 to 2.13) as compared with amoxicillin.
Trimethoprim was associated with a higher risk of AKI and hyperkalemia when compared with other antibiotics used to treat UTIs, but not a greater risk of death. The relative risk increase was similar across population groups, but the higher baseline risk was observed among those taking renin-angiotensin system blockers…
