Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unidentified etiology that is characterized by demolition of osseous matrix and proliferation of vascular structures that ultimately leads to destruction and absorption of bone. This article provides a thorough insight on its pathology, clinical presentation and diagnostic approach. Vanishing bone disease is a rare condition characterized by destruction of osseous matrix and proliferation of vascular structures with benign origin.
Considering its benign character, the prognosis of the entity is unpredictable. Therefore, meticulous research has been done concerning the molecular mechanisms of the disease and possible pharmacological targets are systematically investigated. Etiopathology Vanishing bone disease is an extremely rare idiopathic disease entity affecting the musculoskeletal system and characterized by extensive…
