A 65-year-old male patient suffered from carcinoma lung which metastasized to ribs and femur showing osteolytic bony lesions with extreme bone pain. He is on tab Morphine 15mg 4hrly. 4 weeks ago he received inj zoledronic acid. Now before giving the second dose his sr urea was 35, sr creat 1.8 and corrected calcium 8.6.
No dysuria or polyuria or oliguria. Is it advisable to give the second dose, or should the dose of morphine be reduced before that? What will be the implications if with such picture zoledronic acid is administered, will it worsen the renal failure? Kindly suggest.
