Several studies have linked traffic noise exposure to a higher risk of cardiometabolic disease. To explore the underlying biological pathways, researchers examined the impact of nighttime road traffic noise on cardiometabolic biomarkers using data from the UK Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966 (n = 272,229; adults aged ≥31 years). Compared with noise levels below 45 dB, nighttime road traffic noise of 55 dB or higher was associated with increased levels of 48 metabolites in the UK Biobank cohort.
Of these, 20 metabolites remained robust after meta-analysis and sensitivity testing across cohorts. Higher noise exposure was linked to elevated circulating cholesterol-related biomarkers, including lipids in esterified cholesterol–enriched lipoproteins such as low-density and intermediate-density lipoproteins, as well as unsaturated fatty acids and membrane…
