A 40-year male presents to the psychiatrist with complaints of a depressed mood. He mentions that he is facing depression identical to what he has experienced previously. He was diagnosed with major depression for the first time 20 years ago and was treated with imipramine, up to 150 mg/d, with good results. The second depression episode occurred 15 years ago and was treated with imipramine. But the symptoms remitted after 4 to 6 weeks.

He denies illicit drug use or any recent traumatic events. The man states that although he is sure he is experiencing another major depression, he would like to avoid imipramine this time because it produced unacceptable side effects such as dry mouth, dry eyes, and constipation. What is the best treatment option for this patient? (The answer is posted in the comment section below!) ##Disclaimer## The content provided on Docplexus is intended for…