A 28-year-old man presented himself for an evaluation for primary infertility. The patient abstained from smoking and drinking. He had no history of orchitis.
His 25-year-old wife was healthy, had regular menstrual cycle and never got pregnant. Physical examination Normal, developed penis and bilateral palpable vas deferens Scrotal ultrasound – smaller size of testicular No evidence of variocele Normal volume azoospermia Hormonal profile LH - 6.80 mIU/ml FSH - 29.38 mIU/ml PRL - 17.30 mIU/ml Testosterone - 4.23 ng/ml and Estradiol - 36.00 pg/ml Genetic testing Karyotype 46XY AZF gene – normal Cytogenetic abnormalities – negative Y chromosome microdeletions – negative Testicular biopsy revealed hypospermatogenesis Among aminoglutethimide, tamoxifen, letrozole and anastrozole, which will be more efficacious? (Answer is posted in the comment section below!) *This content is from the…
