For people with celiac disease, gluten is enemy. For some celiac patients, an exposure to gluten can make them sick for days with pain, vomiting and diarrhea while causing intestinal damage. And, maintaining a 100% gluten-free diet can be challenging, creating a great need for therapeutics to help keep the body free of gluten, even if a mistake happens. An experimental new drug may provide relief to celiac disease patients who happen to ingest gluten. At the Digestive Disease Week (DDW) conference, the findings of a phase 2 study of a drug discussed.
The drug, called AMG 714 antibody, leads to fewer symptoms after gluten exposure by blocking interleukin 15. A randomized, double-blind, placebo-controlled, phase 2 study was conducted to test the drug's effectiveness. It was compared to a placebo in celiac disease patients over a 12-week period. A subset of patients received a high-dose…
