Ambrisentan is an endothelin receptor antagonist and indicated in the treatment of pulmonary arterial hypertension. However it is contraindicated in pregnancy and continuous renal and hepatic monitoring is recommended during the treatment. This article gives an overview of indications and contraindications of the Ambrisentan. Ambrisentan is an endothelin receptor antagonists indicated for the treatment of pulmonary hypertension.
The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, and is selective for the type A endothelin receptor. Ambrisentan has shown significant improvement in exercise capacity compared with placebo. Indication: Ambrisentan is indicated for the treatment of pulmonary arterial hypertension (WHO Group 1) in patients with WHO Class II or III symptoms to improve exercise capacity and delay…
