Sickle cell disease or sickle cell anemia is a hereditary hemoglobinopathy. It is a severe form of anemia characterized by abnormal hemoglobin production, hemolytic anemia and recurrent obstruction of small blood vessels. It is observed due to mutation in hemoglobin, which alters the red blood cells into sickle or crescent shape at low oxygen level. This is a concise report of a study carried out to evaluate gonadal hormones in females with sickle cell anemia in correlation with iron overload.
Introduction Sickle cell anemia is a hereditary hemoglobinopathy mainly observed due to abnormal hemoglobin production caused by mutation in beta-gene. The hematological diseases like thalassemia and sickle cell disease are main culprits behind endocrine dysfunction. Though it is unclear in SCD, it is thought that iron storage due to numerous transfusion or ischemia and inflammatory mediators…
