Case presentation A 70-year-old man was admitted to the hospital with melena of 4 days’ duration. He reported a complaint of general fatigue and weight loss over the past two months. An emergent esophagoduodenoscopy revealed a tumor of 7 cm in diameter located at the gastric antrum as a source of bleeding. A gastrointestinal stromal tumor (GIST) was suspected. The patient underwent successful gastric surgery with antrectomy and Billroth-I-reconstruction, with no sign of distant metastasis. No complications occurred in the postoperative course, and the patient recovered well.
Immunohistochemical examination revealed KIT and CD34 expressing tumor cells. These cells were negative for all other markers. The patient was considered at high risk of tumor relapse. He, therefore, received adjuvant treatment with 400 mg of imatinib daily. In the fifth month of therapy, the patient presented with…
