Highlight Ovarian cancer is difficult to identify and often diagnosed at the advanced stage. In addition, 5-year survival rates in ovarian cancer patients are lower than 50%. Cyclooxygenase enzymes mediate the conversion of arachidonic acid to prostaglandins. In addition, COX-2 and prostaglandin production is involved in the progression of cancer by mediating angiogenesis, invasion, and migration of tumor cells.
Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin blocks COX enzymes and can prevent prostaglandins production. Here's a Journal Watch that discusses the “ Common analgesics and ovarian cancer survival: the Ovarian cancer Prognois and Lifestyle (OPAL) study ” published in the Journal of the National Cancer Institute , 2023 . 1 What was the need for the study? Several studies have reported an association between the use of NSAIDs and the survival rate in ovarian…
