Case presentation A 59-year-old man with colon cancer was treated with chemotherapy. He started coughing and had respiratory difficulty two months later. Diffuse bilateral interstitial infiltrates were seen on a chest X-ray . The patient's sputum cultures were negative, and antibiotic therapy was ineffective. Lung biopsy revealed acute and chronic interstitial pneumonitis . Enlarged cells with dark-blue nuclear inclusions were found (Cover image). Question: Which of the following is the most likely causative organism of this patient's pulmonary condition? A.

Cytomegalovirus B. Epstein-Barr virus C. Herpes simplex virus D. Mycoplasma E. Pneumocystis jiroveci Stay tuned for the correct answer! *This image challenge is exclusive from the editorial team of Docplexus for an educative purpose only. Source: Review of Rubin’s Pathology