Previous meta-analyses suggested that cesarean section is associated with increased BMI in offspring Confounding is a concern, even when adjusting for BMI. One approach is to use within-family sibling data to control for environmental factors and shared genetic background. Researcher (JAMA Pediatrics, 2018) sought to determine whether there is an association between mode of delivery and BMI of offspring. So a Retrospective cohort study was conducted where Data derived from the Linked century (Collecting Electronic Nutrition Trajectory Data Using Records of Youth) study.
The Model adjusted for maternal age/ parity / race & ethnicity/ child’s age/ sex/ birth year. Data analyzed to assess within-family component and between-family component and main exposure: was route of delivery. Primary outcomes was age-specific and sex-specific BMI z-score (also called standard deviation score) at 5…
