The gastrointestinal system plays a dominant role in immune system homeostasis. It is the main route of contact with the external environment. The crucial position of the gastrointestinal system is testified by the huge amount of immune cells that reside within it. The immune mechanisms implicated by the gastrointestinal system are very complex and belong to both innate and adaptive immunity. The gastrointestinal system plays a key role in the complex mechanisms of immunoregulation.

Adverse reactions to food resulting in gastrointestinal symptoms have immune-mediated reactions to food allergy. Moreover, gastrointestinal food allergies do exist in both children and adults. The embryonic matrix of the entodermic derivation of respiratory and gastrointestinal tissues confers immunological peculiarities regarding activation of tolerance mechanisms to the digestive system. Concerning…