A team of scientists from Mount Sinai School of Medicine, USA, found that Alzheimer’s patients who were on diabetes medication exhibited a protective effect against Alzheimer’s disease. Treatment with diabetes drugs reduced Alzheimer’s disease-associated alterations in the RNA markers for brain capillary endothelial cells and insulin signaling. This study provides new perspectives into the use of diabetes medicines in the treatment of Alzheimer’s disease.
To examine the protective role of diabetes medicines in Alzheimer’s patients, the researchers examined the brain blood vessels and brain tissues isolated from Alzheimer’s and type 2 diabetic patients, treated with diabetes medicines. Next, they compared them to tissues isolated from non-diabetic Alzheimer’s patients as well as healthy subjects. Results from this study revealed that expression of Alzheimer’s-associated RNA markers for…
