Authors: H Viray, K Li, T A Long, P Vasalos, J A Bridge, L J Jennings, K C Halling, M Hameed, D L Rimm A pathologist visually estimates the fraction of malignant cells in tumor tissue, a critical variable in the accuracy of molecular oncology testing. This approach is not only time-consuming but also can lead to erroneous results. A study was designed to evaluate pathologists’ accuracy in determining the percentage of malignant nuclei as part of the College of American Pathologists (CAP) KRAS-B survey. This ‘ Journal Watch ’ summarizes this study titled “A Prospective, Multi-institutional Diagnostic Trial to Determine Pathologist Accuracy in Estimation of Percentage of Malignant Cells", published in Arch Pathol Lab Med, 2013.
What was the need for the study? Pathologists tend to overestimate the percentage of malignant cells. This is concerning as overestimation errors of more than 20%…
