Dicyclomine most used antispasmodic drug first synthesized in 1947, is an anticholinergic and antimuscarinic effect, drug selectively effective on gastrointestinal and urinary tract. The muscarinic effect seen in organs innervated by parasympathetic nerve, muscarinic receptors m1 to m5 distributed in heart, lungs, sweat glands, git and urinary tract. Dicyclomine selectively works on smooth muscles as antispasmodic and less on gastric secretions, its effective by 2 ways.
Specific anticholinergic effect on smooth muscles as antimuscarinic effect(1/8 as potent as atropine) Direct effect on smooth muscles it reduces the spasm caused by bradykinin and histamine Dicyclomine can be combined with paracetamol, mefenamic acid, clinidium bromide and chlordiazepoxide and available as tab 10 to 20 mgs and injection as dicyclomine hydrochloride for intramuscular use only. Uses: Gastrointestinal…
