Maternal migraine has previously been associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, raising concerns about potential intrauterine effects or shared genetic susceptibility. However, whether this relationship reflects causation or familial confounding remains uncertain. To address this question, a study evaluated the association using multiple analytical approaches, including population-based cohort analyses, family-comparison models, intergenerational polygenic risk score (PRS) analysis, and Mendelian randomization (MR).
Maternal migraine during the first trimester was associated with increased ADHD traits in children (Odds ratio [OR], 1.59), while weaker evidence was observed for partner migraine (OR, 1.31). Maternal migraine PRS was also related to higher ADHD traits at age 7 (OR, 1.21). MR analyses showed limited evidence supporting…
