A high dose of oral ibuprofen offers the highest likelihood of hemodynamically significant patent ductus arteriosus (PDA) closure in preterm infants reported a recent study published in the journal JAMA Network. A recent meta-analysis which included 68 randomized trials with 4802 infants treated with indomethacin, ibuprofen, or acetaminophen reported an overall PDA closure rate of 67% compared with 38% in the placebo group. Furthermore, a high dose of oral ibuprofen was associated with a statistically significantly higher likelihood of hemodynamically significant PDA closure vs standard doses of intravenous ibuprofen or intravenous indomethacin.
Moreover, the placebo group was not associated with an increased likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage. According to you, which pharmacological treatments are associated with the highest likelihood of…
