Homeostatic model assessment (HOMA) is a method for assessing β-cell function and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide concentrations. It has been reported in >500 publications, 20 times more frequently for the estimation of IR than β-cell function. The HOMA model is used to yield an estimate of insulin sensitivity and β-cell function from fasting plasma insulin and glucose concentrations.The relationship between glucose and insulin in the basal state reflects the balance between hepatic glucose output and insulin secretion, which is maintained by a feedback loop between the liver and β-.
HOMA analysis allows assessment of inherent β-cell function and insulin sensitivity and can characterise the pathophysiology in those with abnormal glucose tolerance. Longitudinal data in normal subjects who go on to develop abnormal glucose tolerance is…
