How To Prevent Fluctuating SSNS To FRNS?

It is evidenced that 80% of children with the steroid-sensitive nephrotic syndrome (SSNS) relapse within 2 years and 40-50% of patients have shown frequently-relapsing nephrotic syndrome (FRNS). Likewise, it has been found that patients exhibiting a relapse within 6 months after initial remission were at high risk of FRNS. Therefore, there is a need to develop a treatment to prevent patients from shifting to FRNS .

Based on this, a recent study published in the BMC nephrology reported that use of high-dose mizoribine prevents SSNS patients from shifting to FRNS. Figure 1 . Treatment Regimens Inclusion Criteria: Urinary protein/creatinine ratio : ≥ 1.8 and (b) ≤2.5 g/dL of serum albumin Patients treated by the International Study of Kidney Disease in Children (ISKDC) based regimen at the first episode and relapsed within 6 months after the first remission Age : ≥2 and < 11 years Patients…