A 48-year-old male reported to the hospital with acute pain in the right upper quadrant of the abdomen since the previous day and nausea associated with the pain. Medical history The patient had a history of ankylosing spondylitis and was taking etanercept injections every two weeks to manage his condition. Initial examination Tenderness in the right upper quadrant of the abdomen with no palpable masses. Murphy’s sign was positive. No abnormalities in the vital signs.

Laboratory findings: No abnormalities in the WBCs, liver function tests, C-reactive protein (CRP), and lipase levels. Radiographical findings A CT scan revealed a thick-walled gallbladder with pericholecystic fluid (cover image A). An ultrasound revealed no dilatation of the bile duct, two mobile gallstones, and a distended gall bladder wall of 1.2 cm (cover image B). The patient was diagnosed with acute cholecystitis and…