Despite global efforts to address vaccine-derived poliovirus (VDPV) challenges, a rare case of VDPV transmission has emerged from Kerala, India. VDPV was transmitted from an immune-deficient child to his asymptomatic father, highlighting potential risks of community spread from susceptible individuals. This finding resulted from a comprehensive exercise undertaken by the ICMR-National Institute of Virology, Mumbai, ICMR-National Institute of Immunohematology, and the World Health Organisation. The study involved screening 157 children across India with inborn errors of immunity for poliovirus and non-polio enteroviruses.
One child from Malappuram, who had received two doses of the oral polio vaccine (OPV), was found to excrete the virus. Although other community samples were negative, the child’s father also excreted the same virus. Vaccine-derived polioviruses, a known consequence of…
