Polycystic ovary syndrome (PCOS) affects 5%-10% of women of reproductive age, and it is the most common cause of infertility due to ovarian dysfunction and menstrual irregularity. Several studies have reported that insulin resistance is common in PCOS women, regardless of the body mass index. The importance of insulin resistance in PCOS is also suggested by the fact that insulin-sensitizing compounds have been proposed as putative treatments to solve the hyper insulinemia-induced dysfunction of ovarian response to endogenous gonadotropins.
Rescuing the ovarian response to endogenous gonadotropins reduces hyperandrogenemia and re-establishes menstrual cyclicity and ovulation, increasing the chance of a spontaneous pregnancy. Among the insulin-sensitizing compounds, there is myoinositol (MYO). Previous studies have demonstrated that MYO is capable of restoring spontaneous ovarian…
