Synopsis Osteoarthritis is the most common form of arthritis affecting approximately 250 million people worldwide. The traditional pharmacological approach is mostly limited to symptomatic management of pain using (A) paracetamol and then moving on to (B) NSAIDs , less potent opioids like tramadol (C) and finally to potent opioids such as oxycodone or hydromorphone. Oxaceprol (D) , has been used for the treatment of degenerative joint disease, especially in Europe.
Analgesic efficacy and relatively better tolerability of oxaceprol have been shown in clinical trials conducted in European countries. Thus, the aim of this clinical trial was to compare the efficacy and tolerability of oxaceprol, in comparison to the relatively weak opioid tramadol, in the treatment of symptomatic knee osteoarthritis. This week's ' MED FACT' discusses a clinical trial from Indian Journal Of…
