Tooth sensitivity is often treated with desensitizing toothpastes, which provide only surface-level relief and require frequent use. Seeking a longer-lasting solution, researchers at the Indian Institute of Science and a technology startup have developed CalBots, magnetic nanobots engineered to seal exposed dentinal tubules and restore enamel protection in a single application. CalBots are 400 nanometer-sized particles composed of a calcium silicate-based bioceramic formula.
Guided by an external magnetic field, they penetrate 300–500 micrometers deep into dentinal tubules and self-assemble into cement-like plugs that block nerve pathways. In laboratory tests using extracted human teeth, the nanobots successfully formed durable seals confirmed by high-resolution imaging. In animal studies, mice with induced tooth sensitivity avoided cold water, but after treatment with CalBots, they…
