The presence of maternal red cell antibodies during pregnancy is a common condition and generally requires a close assistance between the laboratory findings, obstetricians and neonatologists. The current article describes the clinical guidelines 2014 for managing red cell antibodies during pregnancy stated by the Royal College of Obstetricians and Gynecologists. The current guidelines cover the management recommendations for fetal anemia caused by red cell antibodies and the early management of the high-risk neonate or hyperbilirubinemia.

The guidelines are as follows: Pre-pregnancy counselling should be advised to the women with red cell antibodies with a risk of fetal anemia or if compatible donor red cells for transfusion may be difficult to obtain. All women should have their blood group and antibody status determined at 28 weeks of gestation. In presence of maternal red cell…