According to a study published on the pre-print platform BioRxiv , researchers from the University of Liverpool and the MRC Laboratory of Molecular Biology in Cambridge have developed a protein-based vaccine directed against SARS-CoV-2 that could be used as an alternative to the existing mRNA-based vaccines. Researchers found that Ferritin-like protein isolated from the archaeon, Sulfolobus islandicus can be covalently coupled with different antigens from SARS-CoV-2 to form highly stable vaccine nanoparticles . These multivalent dodecameric vaccine nanoparticles completely protected mice from SARS-CoV-2-associated pneumonia and disease progression, even with a single shot.
Researchers developed a stable, convenient, and non-bacterial scaffold that would allow the display and multimerization of various SARS-CoV-2 antigens. The Dps protein isolated from the archaeon Sulfolobus islandicus…
