Several studies have demonstrated the possible mechanisms revolving around Crohn's disease with several established treatment modalities. However, the expected results are not achieved. Interestingly, in a breakthrough research, it was established that it is not the programmed cell death ligand-1 but the programmed cell death ligand-2 that drives the pathology of Crohn's disease. The present article delves deep into the underlying programmed cell death ligand-2-mediated mechanism of Crohn's disease and sheds light on the possible new treatments.
Introduction Crohn’s disease (CD) is predominantly an inflammation of the ileum. The pathophysiology behind the disease is considered to be driven by the expression of programmed cell death ligand-1 (PDL1), which is known to increase cytokine production, thus resulting in autoimmunity. However, recent studies have demonstrated that it is not the…
