While life-expectancy is longer now-a-days, age-related problems remain major medical concerns. One such growing issue is osteoporosis. Aging itself is the leading risk factor as well as the underlying mechanism. One of the fundamental aging mechanisms is cellular senescence.
With aging, senescence cells increase in the bone microenvironment producing a pro-inflammatory secretome leading to increased bone resorption. Evidence from animal studies shows that techniques that eliminate senescent cells or suppress the proinflammatory secretome prevent age-related bone loss. Therefore, targeting senescent cells presents a new therapeutic paradigm to control osteoporosis or other aging comorbidities.
