Intramuscular injection is the most preferred route of administration by medical professionals to achieve a quick and effective response. However, it is associated with a very rare complication leading to local ischemic necrosis of skin and adipose tissue called as Nicolau syndrome. This article focuses on few important points of Nicolau Syndrome. IM is a route of choice for the administration of many drugs in various treatments.
Quick and effective response are major advantages of IM route of administration. Conversely, it is associated with few known and severe complication like sciatic nerve injury along with a rare complication known as Nicolau syndrome. It is also described as embolic cutis medicamentosa and livedoid dermatitis. Nicolau syndrome is characterized by pain at injection site, hyperemia, skin discoloration, redness, abscess formation, and local ischemic necrosis…
