A bladder cancer sufferer was found with unusual Beta2-microglobulinic amyloidosis (ABeta2M amyloidosis) depositions despite no routine aetiological features. Combined efforts of the doctors brought a case of 80 something years old patient’s pathology to a conclusion. Clinical features: Bladder cancer Histopathology - minor amounts of Amyloid deposition in the small‐vessel wall of the peripheral urothelial carcinoma and necrotic area. Immunohistochemistry - Strong, positive Amyloid typing for the anti‐Beta2‐m antibody and Beta2‐m detected in laser microdissection‐LC tandem MS.
Beta2‐m level- Mere 4 mg/L in serum, and in urine elevated to 1340 mg/L. Novel Diagnosis: Novel pathogenesis of ABeta2M amyloid fibril formation in patient with NO history of dialysis. Treatment: Transurethral resection of bladder cancer Source: Pathology International Answer is published in the Comments Section…
