Histologic scoring systems for the chronic liver disease are used to characterize and predict disease progression, to determine prognosis, to guide treatment strategies, and to provide standards in clinical trials. This article will provide a brief summary of these scoring systems. During the chronic liver disease, assessment by liver biopsy is one key factor that decide the disease stage, progression rate and possible treatment plan for the patients. The liver biopsy procedure has few limitations such as: Variable quality of liver biopsy specimens: Specimens shorter than 2 cm in length may be difficult to interpret for conclusive results.
Larger caliber needles may yield better samples than fine needle biopsies. For example, small specimens may underestimate the degree of inflammatory activity and fibrosis in patients with viral hepatitis. Sampling variability: The assessment of liver…
