The diagnosis of small prostate cancer foci pose a real challenge for pathologists and urologists since it carries a risk of false positive or negative diagnosis along with clinical consequences. The diagnosis requires a strict methodological approach which includes a search for major and minor features under low and high magnification. Prostate cancer (PC) is predominantly a disease of older men but around 20% of cases occur in men under the age of 65.
Over the past 10 to 15 years there have been a number of significant advances in its management but also a number of major controversies, especially about the clinical management of patients with early, non-metastatic disease. Moreover, over detection may be an important issue given that many men who develop prostate cancer do not either develop clinically relevant disease or die as a result of their disease. Associated with this concern…
