A 12-year-old Canadian boy with a bright yellow tongue was diagnosed with cold agglutinin disease, a rare autoimmune disorder in which the body’s immune cells destroy its red blood cells (RBCs). In a recent report published in The New England Journal of Medicine , a Canadian boy of 12 years was found to have a rare autoimmune disease that causes bright yellow coloration of the tongue. On initial arrival to the clinic at the Hospital for Sick Children in Toronto, the boy was diagnosed with jaundice, given the clinical presentation of dark urine, abdominal pain, sore throat, and pallor for the last three to four days.

Lab examinations revealed a low hemoglobin count, abnormally high levels of lactate dehydrogenase, and unconjugated bilirubin. To confirm the diagnosis, the following tests were performed: A positive antiglobulin test detected the presence of cold agglutinins. Urinalysis…