Rosettes are formed due to a halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub could be an empty lumen or a space filled with cytoplasmic processes. The individual cells of the rosette are usually wedge-shaped, with their apex directed towards the central core. The nuclei of these cells are generally positioned peripherally.
Rosettes can be primary or secondary manifestations of the tumor architecture. Primary rosettes result from the characteristic growth pattern of a given tumor, whereas secondary rosettes occur due to the influence of external factors on tumor growth and development. In pseudorosettes, the central hub or core is not formed by the tumor itself; instead, it represents a native, non-neoplastic element. Rosettes and pseudorosettes are not entirely pathognomonic; however, they provide important clues for diagnosing certain…
