The fact that delayed onset of puberty is mainly observed in children with hypothyroidism is well-documented; however, there is less evidence for the effect of thyrotoxicosis on pubertal development. A recent study published in Clinical Pediatric Endocrinology reported a case of a girl diagnosed with Graves’ disease (GD) at two years of age, and reached puberty at an early age. A preoperative examination for craniosynostosis showed thyrotoxicosis. According to the study, she was tall, and her bone age was progressive at GD onset; her linear growth decreased after the commencement of anti-thyroid treatment.
Moreover, breast budding was recognized at nearly six years of age. Hormonal analysis revealed pubertal levels of luteinizing hormone (LH) response to a gonadotrophin-releasing hormone (GnRH) stimulation test and serum E2. Based on this, gonadal suppression therapy with GnRH agonist…
