Increased fasting Insulin level is a widely used surrogate measure of insulin resistance and predicts type 2 diabetes in various populations. Whether fasting hyperinsulinemia predicts diabetes independent of insulin resistance is unknown. In non-diabetic, normotensive overweight individuals, serum triglyceride concentration, the ratio of triglyceride to high density lipoprotein (HDL) cholesterol concentrations, and fasting insulin concentration are useful markers for identifying those who may be insulin resistant.
Optimal cut-points were identified as 130 mg/dL (1.47 mmol/L)- for triglycerides 3.0 (1.8 SI units)- triglyceride-to HDL ratio and insulin-15.7 µU/mL (109 pmol/L) respectively.Sensitivity and specificity for the cut-points were 67, 64, and 57 percent, respectively, and 71, 68, and 85 percent, respectively. In large population epidemiology studies, simple ratios derived from…
