Magnesium plays a critical role in a variety of physiologic processes. Ever since the study of magnesium sulphate in clinical anesthesia begin in 1996, magnesium has drawn attention in the field of anesthesia and pain medicine. Recently, numerous clinical studies have reported its efficacy in terms of analgesia and muscle relaxation in surgical patients. Among the numerous actions of magnesium, the blockade of N-methyl-D-aspartate (NMDA) receptor and calcium channel has an important meaning to anesthesia. The normal range of magnesium in plasma is 0.7-1.1 mmol/L (1.4-2.2 mEq/L).
Hypomagnesemia can occur. Hypermagnesia occurs rarely in clinical medicine unless the renal function of the patient is compromised. If the plasma concentration of magnesium reaches 4-5 mmol/L, toxic symptoms such as loss of deep tendon reflex and dizziness can occur. Magnesium sulphate has been used in…
