The American Gastroenterological Association (AGA) Clinical Practice Guideline Committee developed guidelines on the initial management of acute pancreatitis within the first 48-72 hours of admission. This period is significant as appropriate and timely management can influence the course of disease and duration of hospitalization. The guideline has challenged many traditional practices that have continued over the years in the management of acute pancreatitis and includes many new recommendations such as goal-directed fluid replacement, early (within 24 hours) enteral feeding including for those who are unable to tolerate oral feeding, and cholecystectomy prior to discharge for patients with biliary pancreatitis.

Some key recommendations are: Goal-directed therapy for fluid management is recommended; the guideline advice against the use of hydroxyethyl starch fluids. Prophylactic…