Sugammadex is an agent for reversal of neuromuscular blockade by the rocuronium. It is the first selective relaxant binding agent. Mechanism of action: Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery. Their three-dimensional structure resembles a hollow truncated cone.
The structure has a hydrophobic cavity and a hydrophilic exterior. Hydrophobic interactions trap the drug in the cyclodextrin cavity (the “doughnut hole”), thereby resulting in the formation of a water-soluble guesthost complex. unmodified γ-cyclodextrin possesses a larger lipophilic cavity (7.5 to 8.3 Å) than any other cyclodextrin does, it is still not deep enough to accommodate the larger rigid structure of the rocuronium molecule. Therefore, the cavity was modified by adding eight side chains to enlarge the cavity for better accommodation of rocuronium and by adding…
