Chronic daily headache (CDH) is a term used for primary headaches occurring in more than fourteen days per month. The process of transformation of episodic headache into chronic daily headache is accompanied by increased use of analgesics and migraine drugs. Chronic Migraine (CM) is a complex, progressive headache disorder affecting approximately 1.3-2.4% of the general population. It occurs for more than fifteen days/month for at least three consecutive months, with headache having the clinical features of migraine with or without aura for at least eight days per month.

Few preventive treatments have been investigated and none is specifically indicated for chronic migraine. Treating headache Patients with chronic migraine often find it difficult to know when to take acute treatments. Both patients and physicians may be concerned about the possibility of medication overuse, and in the…